Author:
Song Shu-Ting,Wu Meng-Li,Zhang Hai-Jiao,Su Xiao,Wang Jian-Hua
Abstract
Graphical AbstractRetrovirus-induced MC degranulation promotes acute viral infection. The acute infection of MuLV/Friend virus triggers MC degranulation, which activates G-MDSCs to inhibit both CD8+ T- and NK cell-mediated antiviral immune responses; the HR1 antagonists Eastine and Loratadine that being used as the MC stabilizers block MC degranulation and consequently reverse degranulation-induced immune suppression for viral suppression. G-MDSCs, granulocyte-like myeloid derived suppressive cells; HR1, histamine receptor 1; iNOS, inducible nitric oxide synthase; MC, mast cell.
Subject
Microbiology (medical),Microbiology
Cited by
10 articles.
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