Author:
Lv Dongli,Xia Jinmei,Guan Xiaoqing,Lai Qiliang,Zhang Beibei,Lin Jianhui,Shao Zongze,Luo Sulan,Zhangsun Dongting,Qin Jiang-Jiang,Wang Weiyi
Abstract
Two new indole diketopiperazines (1–2) obtained from the fermentation culture of a deep-sea-derived fungus Aspergillus chevalieri MCCC M23426, were characterized, together with nine biogenetic related compounds (3–11). The structures of 1–2 were assigned based on NMR, MS, NMR calculation, DP4+ analysis, and ECD calculation. The bioactive assay showed that compounds 1, 5–7 significantly inhibited the growth of Staphylococcus aureus. Meanwhile, compound 8 potently reduced the cell viability of gastric cancer cell MKN1 with an IC50 value of 4.6 μM.
Funder
Natural Science Foundation of Fujian Province
National Natural Science Foundation of China
Subject
Microbiology (medical),Microbiology
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