Author:
Pan Guojun,Zhao Yanfen,Ren Shuang,Liu Fengyang,Xu Qicai,Pan Weibin,Yang Tongtao,Yang Mingtian,Zhang Xinru,Peng Chuanyue,Hao Gangping,Kong Fandong,Zhou Liman,Xiao Na
Abstract
Four new indole-terpenoids (1–4) named encindolene A, 18-O-methyl-encindolene A, encindolene B, and encindolene C, as well as three known analogs (5–7), were isolated from the fungus Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne. The structures of compounds including absolute configurations were elucidated by spectroscopic data and electronic circular dichroism (ECD) analysis. Anti-inflammatory activity evaluation revealed that compounds 1–7 inhibit the production of nitric oxide with IC50 values of 79.4, 49.7, 81.3, 40.2, 86.7, 90.1, and 54.4 μM, respectively, and decrease the levels of tumor necrosis factor-α, interleukin-6 contents in lipopolysaccharide-induced RAW264.7 macrophages.
Subject
Microbiology (medical),Microbiology
Cited by
8 articles.
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