Author:
Li Minghui,Xie Si,Bi Xiaoyue,Sun Fangfang,Zeng Zhan,Deng Wen,Jiang Tingting,Lin Yanjie,Yang Liu,Lu Yao,Zhang Lu,Yi Wei,Xie Yao
Abstract
BackgroundTo investigate the effect of intermittent interferon therapy mode on the disappearance of hepatitis B surface antigen (HBsAg) in chronic hepatitis B (CHB) patients.MethodsThis is a retrospective cohort study in CHB patients who were suspended from pegylated interferon α (PEG-IFNα) therapy due to a plateau in HBsAg decline during the initial treatment period, and resumed interferon therapy after an interval of 3–6 months. Patients received entecavir or tenofovir during the interval period. Hepatitis B virus (HBV) virological and serological indexes, clinical biochemical indexes, and blood routine tests were performed at the baseline and every 3 months during follow-up of initial interferon treatment. A functional cure was analyzed as a primary outcome.ResultsA total of 304 patients treated with intermittent PEG-IFNα were included in the statistical analysis, including 215 men and 89 women, aged 37.97 ± 8.53 years, and 73 hepatitis B e antigen (HBeAg)-negative and 231 HBeAg positive patients. In total 59 patients (19.41%) achieved HBsAg disappearance through the initial, intermittent, and retreatment of PEG-IFNα treatment, of whom 43 patients (14.14%) achieved HBsAg seroconversion. Early HBsAg response to initial treatment was significantly associated with HBsAg response at 12 and 24 weeks of retreatment. After the intermission period, the incidence of HBsAg disappearance in patients with early HBsAg response in the retreatment period was 43.87%. The baseline HBsAg and 12-week HBsAg response in the retreatment period had higher predictive value than the initial treatment HBsAg response.ConclusionThe initial, intermittent, and retreatment mode of interferon can help to improve the HBsAg disappearance rate in CHB patients.Clinical trial registration[www.ClinicalTrials.gov], identifier [NCT04028856].
Funder
National Science and Technology Major Project
Digestive Medical Coordinated Development Center of Beijing Hospitals Authority
Beijing Municipal Science and Technology Commission
Subject
Microbiology (medical),Microbiology
Reference32 articles.
1. Peginterferon alpha-2b is safe and effective in HBeAg-positive chronic hepatitis B patients with advanced fibrosis.;Buster;Hepatology,2007
2. Quantitation of plasmacytoid dendritic cells in chronic hepatitis B patients with HBeAg positivity during PEG-IFN and entecavir therapy.;Cao;J. Interferon. Cytokine Res.,2018
3. The Characteristics of Natural killer cells in chronic hepatitis B patients who received PEGylated-interferon versus entecavir therapy.;Cao;Biomed. Res. Int.,2021
4. [The guidelines of prevention and treatment for chronic hepatitis B (2019 version)].;Zhonghua Gan Zang Bing Za Zhi,2019
5. [The guideline of prevention and treatment for chronic hepatitis B: A 2015 update].;Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Infectious Diseases, Chinese Medical Association, Hou;Zhonghua Gan Zang Bing Za Zhi,2015
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献