Regulation and Evasion of Host Immune Response by African Swine Fever Virus

Author:

Wu Lei,Yang Bincai,Yuan Xu,Hong Jinxuan,Peng Min,Chen Ji-Long,Song Zhongbao

Abstract

African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-stranded DNA virus belonging to the Asfarviridae family. Here, we review how the virus regulates the host immune response and its mechanisms at different levels, including interferon modulation, inflammation, apoptosis, antigen presentation, and cellular immunity.

Funder

Natural Science Foundation of Fujian Province

Publisher

Frontiers Media SA

Subject

Microbiology (medical),Microbiology

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