Author:
Hau Nguyen Viet,Han Luu Thi Kim,Minh Le Huu Nhat,Kiet Nguyen Anh,Phong Tang Tuan,Duong Nguyen Khanh,Yen Phan Thi Hoang,Vinh Nguyen Xuan,Hao Nguyen Quan Nhu,Nguyen Nguyen,Truyen Thien Tan Tri Tai,Le Nguyen Quoc Khanh
Abstract
Coronary artery vasospasm (CVS), an uncommon cause of acute chest pain, can be provoked by vasoconstriction-induced medications. Misoprostol, a prostaglandin analog, is a safe medication to terminate a pregnancy. However, misoprostol can cause coronary artery vasospasm due to vasoconstrictor properties, leading to acute myocardial infarction with nonobstructive coronary arteries (MINOCA), especially in patients with a high risk for cardiovascular disease. We report a case of a 42-year-old female with a past medical history of hypertension who presented with ST-elevation myocardial infarction following the administration of a high-dose Misoprostol. The fact that coronary angiogram and intravascular ultrasound revealed normal coronary arteries suggested transient coronary vasospasm. CVS is a severe but rare cardiac adverse effect associated with high-dose misoprostol. This medication should be prescribed with caution and close monitoring, especially in those with pre-existing heart disease or cardiovascular risk factors. Our case raises awareness of severe cardiovascular complications that can be related to using misoprostol in high-risk patients.
Subject
Cardiology and Cardiovascular Medicine
Cited by
2 articles.
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