Author:
Mauersberger Carina,Hinterdobler Julia,Schunkert Heribert,Kessler Thorsten,Sager Hendrik B.
Abstract
Atherosclerosis is the leading cause of death worldwide and leukocyte recruitment is a key element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in concert with accumulating lipids, the invading leukocytes trigger a plethora of inflammatory responses which promote the influx of additional leukocytes and lead to the continued growth of atherosclerotic plaques. The recruitment process follows a precise scheme of tethering, rolling, firm arrest, crawling and transmigration and involves multiple cellular and subcellular players. This review aims to provide a comprehensive up-to-date insight into the process of leukocyte recruitment relevant to atherosclerosis, each from the perspective of endothelial cells, monocytes and macrophages, neutrophils, T lymphocytes and platelets. In addition, therapeutic options targeting leukocyte recruitment into atherosclerotic lesions—or potentially arising from the growing body of insights into its precise mechanisms—are highlighted.
Funder
European Research Council
Else Kröner-Fresenius-Stiftung
Deutsche Herzstiftung
Deutsche Forschungsgemeinschaft
Subject
Cardiology and Cardiovascular Medicine
Cited by
32 articles.
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