Short-Chain Fatty Acids in the Metabolism of Heart Failure – Rethinking the Fat Stigma

Author:

Palm Constantin L.,Nijholt Kirsten T.,Bakker Barbara M.,Westenbrink B. Daan

Abstract

Heart failure (HF) remains a disease with immense global health burden. During the development of HF, the myocardium and therefore cardiac metabolism undergoes specific changes, with decreased long-chain fatty acid oxidation and increased anaerobic glycolysis, diminishing the overall energy yield. Based on the dogma that the failing heart is oxygen-deprived and on the fact that carbohydrates are more oxygen-efficient than FA, metabolic HF drugs have so far aimed to stimulate glucose oxidation or inhibit FA oxidation. Unfortunately, these treatments have failed to provide meaningful clinical benefits. We believe it is time to rethink the concept that fat is harmful to the failing heart. In this review we discuss accumulating evidence that short-chain fatty acids (SCFAs) may be an effective fuel for the failing heart. In contrast to long-chain fatty acids, SCFAs are readily taken up and oxidized by the heart and could serve as a nutraceutical treatment strategy. In addition, we discuss how SCFAs activate pathways that increase long chain fatty acid oxidation, which could help increase the overall energy availability. Another potential beneficial effect we discuss lies within the anti-inflammatory effect of SCFAs, which has shown to inhibit cardiac fibrosis – a key pathological process in the development of HF.

Publisher

Frontiers Media SA

Subject

Cardiology and Cardiovascular Medicine

Reference73 articles.

1. Epidemiology and aetiology of heart failure;Ziaeian;Nat Rev Cardiol.,2016

2. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure;McDonagh;Eur Heart J,2021

3. The pathogenesis of cardiac fibrosis;Kong;Cell Mol Life Sci NIH Public Access,2014

4. Cardiac energy metabolism in heart failure;Lopaschuk;Circ Res,2021

5. Metabolic remodelling in heart failure;Bertero;Nat Rev Cardiol.,2018

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