Abstract
This story is about the invention of transcatheter aortic valve implantation (TAVI), and the people who transformed it from a concept and primitive device to a breakthrough lifesaving treatment for hundreds of thousands of patients with aortic valve stenosis. It is an inspirational example of a new disruptive technology that began with an idea most dismissed. The story describes the ups and downs from idea, design, construction, animal testing, proof-of-concept, scientific publication hurdles, a patent, license agreement, cooperation with several companies, fighting in patent courts in Europe and USA and finally how multinational companies financially bypassed the inventor. It is also a story about the struggles and battles the inventor experienced when injected into a world of lawyers and patent fights. I hope my personal story and journey can provide an inspiration and word of caution for new inventors.
Subject
Cardiology and Cardiovascular Medicine
Reference47 articles.
1. The surgical correction of aortic regurgitation;Hufnagel;Prelim Rep Bull Georgetown Univ Center.,1953
2. Surgical correction of aortic insufficiency;Hufnagel;Surgery.,1954
3. Transluminal implantation of artificial heart valves. Description of a new expandable aortic valve and initial results with implantation by catheter technique in closed chest pigs;Andersen;Eur Heart J.,1992
4. Catheter-implanted prosthetic valves. Transluminal catheter implantation of a new expandable artificial heart valve in the descending aorta in isolated vessels and closed chest pig.s Int J Artif Organs;Knudsen,1993
5. Transluminal catheter implantation of a new expandable artificial heart valve in the descending thoracic aorta in isolated vessels and closed chest pigs;Knudsen;Eur Heart J.,1992
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献