Author:
Villalobos-Pedroza Montserrat,Hernandez-Pastrana Sarai,Arias-Mendoza Alexandra,Latapi-Ruiz Esparza Ximena,Robles-Ledesma Mariana,Guerrero-Ochoa Alejandra,Milanes-Gonzalez Nelson Antonio,Solis-Jimenez Fabio,Sierra Gonzalez-De Cossio Alejandro,Flores-Batres Alejandro Pablo,Brindis-Aranda Arielle Astrid,Rivera-Pedrote Edgar,Jara-Nevarez Alejandra,Gonzalez-Macedo Eder,Gopar-Nieto Rodrigo,Gonzalez-Pacheco Héctor,Briseño-De la Cruz Jose Luis,Araiza-Garaygordobil Diego
Abstract
IntroductionIn developing countries, there is a notable scarcity of real-world data on adherence to optimal medical therapy (OMT) and its correlation with major cardiovascular adverse events (MACEs) after ST-elevation myocardial infarction (STEMI). Our study focuses on addressing this gap by evaluating adherence to OMT, examining its influence on the risk of MACEs after STEMI, and assessing subsequent cardiovascular risk factor control in Mexico.MethodsWe conducted a prospective observational study of post-STEMI patients after hospital discharge. Adherence to treatment was assessed over a median of 683 days (interquartile range: 478–833) using the Simplified Medication Adherence Questionnaire (SMAQ). Patients were followed up for 4.5 years to monitor MACEs (cardiovascular death, cardiogenic shock, recurrent myocardial infarction, and heart failure).ResultsWe included 349 patients with a mean age of 58.08 years (±10.9), predominantly male (89.9%). Hypertension (42.4%), smoking (34.3%), type 2 diabetes mellitus (31.2%), obesity (22.92%), and dyslipidemia (21.4%) were highly prevalent. Adherence to OMT per SMAQ was 44.7%. The baseline clinical characteristics of adherent and non-adherent patients did not significantly differ. OMT prescription rates were as follows: acetylsalicylic acid, 91.1%; P2Y12 inhibitors, 76.5%; and high-intensity statins, 86.6%. While non-adherent patients had a numerically higher rate of MACEs (73 vs. 49 first events), there was no statistically significant difference (hazard ratio 1.30, 95% confidence interval 0.90–1.88).DiscussionIn this real-world study of patients after STEMI, we observed low adherence to OMT, a low proportion of global cardiovascular risk factor control, and a numerically higher incidence of recurrent major adverse cardiovascular events in non-adherent patients. Strategies to improve adherence to OMT and risk factor control are needed.