Successful pharmaco-invasive approach using a lower alteplase dose and VA-ECMO support in high-risk pulmonary embolism: case report

Author:

Gutierrez-Gallegos Paola,Jimenez-Franco Vicente,Jerjes-Sanchez Carlos,Quevedo-Salazar Renata,Rodriguez-Rivera Jahir,Paredes-Gutierrez Enrique,Lira-Lozano Daniel,Quintanilla-Gutierrez Juan,Gomez-Gutierrez Rene,de la Peña-Almaguer Erasmo,Torre-Amione Guillermo

Abstract

Despite the elevated mortality rates associated with high-risk pulmonary embolism (PE), this condition remains understudied. Data regarding the effectiveness and safety of invasive therapies such as venoarterial extracorporeal membrane oxygenation (VA-ECMO) in this patient population remains controversial. Here, we present the case of a 61-year-old male with high-risk PE associated with refractory cardiac arrest and cardiogenic shock who underwent a combination of extracorporeal cardiopulmonary resuscitation with VA-ECMO and pharmaco-invasive therapy (mechanical thrombi fragmentation plus lower alteplase dose), resulting in successful pulmonary reperfusion. After a prolonged in-hospital stay, the patient was discharged in stable condition.

Publisher

Frontiers Media SA

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