Author:
Jaques David A.,Vollenweider Peter,Bochud Murielle,Ponte Belen
Abstract
BackgroundAging is associated with a physiological decline in kidney function (KFD). In this study, we aimed to describe the impact of age on the rate of KFD and its interplay with risk factors for chronic kidney disease (CKD), considering mainly hypertension (HT), in the general population.Materials and methodsParticipants of European descent, aged 35–75, were recruited from a populational cohort in Lausanne, Switzerland. Participants with a 10 year follow-up were selected. KFD was defined as the difference in estimated glomerular filtration rate (eGFR) between baseline and follow-up, divided by the observation period. Multivariate linear regressions were used with KFD as the outcome and age as the main predictor. HT was tested as a modifying factor.ResultsWe included 4,163 participants with mean age 52.2 ± 10.4, 44.7% men, 31.9% HT, and 5.0% diabetics. Mean baseline eGFR was 85.9 ± 14.6 ml/min/1.73 m2. Mean KFD was –0.49 ± 1.08 ml/min/1.73 m2 per year with 70% of participants decreasing their eGFR during follow-up. The relationship between age and KFD was non-linear and age was divided in tertiles. Old participants had faster rates of KFD as compared to young and middle-age participants (p < 0.001). A significant interaction was found between age and HT on KFD prediction (p < 0.001). In HT participants, KFD was significantly different across tertiles of age (p < 0.001). On contrary, KFD was not different across tertiles of age in non-HT participants.ConclusionA physiological KFD is present over time in the general population. Age contributes non-linearly to the rate of this decline with older subjects declining the fastest. The presence of HT is a major contributing factor in this setting as KFD worsened with age only in hypertensive participants. Thus, HT represents an important pathological factor aggravating the age-related physiological decline in eGFR in the general population.
Funder
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
GlaxoSmithKline
Université de Lausanne
Subject
Cardiology and Cardiovascular Medicine
Reference46 articles.
1. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.;Go;N Engl J Med.,2004
2. Chronic kidney disease: definition, updated epidemiology, staging, and mechanisms of increased cardiovascular risk.;Wilson;J Clin Hypertens.,2021
3. CKD prevalence varies across the European general population.;Brück;J Am Soc Nephrol.,2016
4. Prevalence and determinants of chronic kidney disease in the Swiss population.;Forni Ogna;Swiss Med Wkly.,2016
5. Two novel equations to estimate kidney function in persons aged 70 years or older.;Schaeffner;Ann Intern Med.,2012
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献