Author:
Sharifi-Rad Javad,Quispe Cristina,Mukazhanova Zhazira,Knut Ewa,Turgumbayeva Aknur,Kipchakbayeva Aliya,Seitimova Gulnaz,Mahomoodally Mohamad Fawzi,Lobine Devina,Koay Aaron,Wang Jinfan,Sheridan Helen,Leyva-Gómez Gerardo,Prado-Audelo María L. Del,Cortes Hernán,Rescigno Antonio,Zucca Paolo,Sytar Oksana,Imran Muhammad,Rodrigues Célia F.,Cruz-Martins Natália,Ekiert Halina,Kumar Manoj,Abdull Razis Ahmad Faizal,Sunusi Usman,Kamal Ramla Muhammad,Szopa Agnieszka
Abstract
Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry
Reference182 articles.
1. Recent advances in nanoencapsulation systems using PLGA of bioactive phenolics for protection against chronic diseases;Abdul Rahim;Int. J. Environ. Res. Public Health,2019
2. Resource the molecular taxonomy of primary prostate cancer;Abstract;Cell Press,2015
3. Contemporary formulations for drug delivery of anticancer bioactive compounds;Ackova;Recent Patents Anti Canc. Drug Discov.,2019
4. Assay of resveratrol and derivative stilbenes in wines by direct injection high performance liquid chromatography;Adrian;Am. J. Enol. Vitic.,2000
5. Role of resveratrol in prevention and therapy of cancer : preclinical and clinical studies;Aggarwal;Anticancer Res.,2004
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