Remote Optogenetics Using Up/Down-Conversion Phosphors

Author:

Matsubara Takanori,Yamashita Takayuki

Abstract

Microbial rhodopsins widely used for optogenetics are sensitive to light in the visible spectrum. As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body. Conventional optogenetics employs fiber optics inserted close to the target, which is highly invasive and poses various problems for researchers. Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors. The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues. Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.

Funder

Japan Society for the Promotion of Science

Japan Science and Technology Agency

Uehara Memorial Foundation

Asahi Glass Foundation

Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care

Publisher

Frontiers Media SA

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry

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1. Probing the optical properties and toxicological profile of zinc tungstate nanorods;The Journal of Chemical Physics;2024-06-17

2. Nano-optogenetics for Disease Therapies;ACS Nano;2024-05-20

3. Tetherless Optical Neuromodulation: Wavelength from Orange-red to Mid-infrared;Neuroscience Bulletin;2024-02-19

4. Exploration of X-ray Fluorescence Emission Tomography for Imaging Micro-Scintillators used in Remote Optogenetics Application;2023 IEEE Nuclear Science Symposium, Medical Imaging Conference and International Symposium on Room-Temperature Semiconductor Detectors (NSS MIC RTSD);2023-11-04

5. What makes a medical intervention invasive?;Journal of Medical Ethics;2023-09-18

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