Author:
Nicoletti Carolina F.,Roschel Hamilton,Merege-Filho Carlos,Lima Alisson P.,Gil Saulo,Pinhel Marcela A. S.,Noronha Natalia Y.,Santo Marco A.,Jacome Amalia,Crujeiras Ana B.,Gualano Bruno,Nonino Carla B.
Abstract
Exercise training and bariatric surgery have been shown to independently modulate DNA methylation profile in clusters of genes related to metabolic and inflammatory pathways. This study aimed to investigate the effects of a 6-month exercise training program on DNA methylation profile in women who underwent bariatric surgery. In this exploratory, quasi-experimental study, we analyzed DNA methylation levels by array technology in eleven women who underwent Roux-en-Y Gastric Bypass and a 6-month, three-times-a-week, supervised exercise training program. Epigenome Wide Association Analysis showed 722 CpG sites with different methylation level equal to or greater than 5% (P < 0.01) after exercise training. Some of these CpGs sites were related to pathophysiological mechanisms of inflammation, specially Th17 cell differentiation (FDR value < 0.05 and P < 0.001). Our data showed epigenetic modification in specific CpG sites related to Th17 cell differentiation pathway in post-bariatric women following a 6-months exercise training program.
Subject
Public Health, Environmental and Occupational Health,Tourism, Leisure and Hospitality Management,Anthropology,Orthopedics and Sports Medicine,Physical Therapy, Sports Therapy and Rehabilitation,Physiology
Cited by
1 articles.
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