Author:
Moreno Carlos M.,Boeree Ellie,Freitas Claudia M. Tellez,Weber K. Scott
Abstract
In recent years, the interplay between oral microbiota and systemic disease has gained attention as poor oral health is associated with several pathologies. The oral microbiota plays a role in the maintenance of overall health, and its dysbiosis influences chronic inflammation and the pathogenesis of gum diseases. Periodontitis has also been associated with other diseases and health complications such as cancer, neurogenerative and autoimmune disorders, chronic kidney disease, cardiovascular diseases, rheumatic arthritis, respiratory health, and adverse pregnancy outcomes. The host microbiota can influence immune cell development and immune responses, and recent evidence suggests that changes in oral microbiota composition may also contribute to sensitization and the development of allergic reactions, including asthma and peanut allergies. Conversely, there is also evidence that allergic reactions within the gut may contribute to alterations in oral microbiota composition. Here we review the current evidence of the role of the oral microbiota in inflammatory diseases and health complications, as well as its future relevance in improving health and ameliorating allergic disease.
Subject
General Earth and Planetary Sciences
Reference125 articles.
1. Interaction between microbiota and immunity in health and disease;Zheng;Cell Res,2020
2. Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus;Umesaki;Immunology,1993
3. Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice;Tan;Proc Natl Acad Sci U S A,2016
4. The response of the lymphatic tissue to the microbial flora. Studies on germfree mice;Bauer;Am J Pathol,1963
5. Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis;Kawamoto;Immunity,2014
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献