THE EFFECT OF ASCENDING DOSES OF KETOPROFEN ON BIOCHEMICAL AND COAGULATION PARAMETERS IN LAMBS

Author:

Ural Mehmet NihatORCID,Üney KamilORCID

Abstract

Ketoprofen (KTP) is a non-steroidal anti-inflammatory drug (NSAID) used as an analgesic, antipyretic and anti-inflammatory agent in human and veterinary medicine. Although KTP is used in the treatment of diseases such as musculoskeletal inflammation, endotoxemia, pneumonia, enteritis in sheep and minor surgical procedures such as dehorning and castration there is no information about its safety. The aim of this study is to determine the effect of KTP on biochemical and coagulation parameters following intramuscular (IM) administration of different doses of KTP to lambs. In the study, 18 clinically healthy lambs were randomly divided into three groups of 6 animals each. KTP was administered IM to lambs at doses of 1.5, 3 and 6 mg/kg. Biochemical and coagulation parameters were evaluated by taking blood samples before drug administration (0 hour) and at 24 hours and 48 hours after administration. No local or systemic side effects were observed in lambs after the administration of KTP at different doses. The aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LDH) values at 24 hours significantly increased compared to 0 hours in all dosage groups (p<0.05). KTP did not cause a significant change in albumin (ALB), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine (CRE), CK and LDH values in different dose groups. The AST value was only significantly higher in the 6 mg/ kg dose group compared to the 1.5 mg/kg dose group at 24 hours (p<0.05). Although there was no statistically significant difference in intragroup prothrombin time (PT), fibrinogen and D-dimer levels in all dose groups, a significant increase was observed in the activated partial thromboplastin time (aPTT) value of 6 mg/kg dose group at the 24 hours compared to the 0 hour (p<0.05). As a result, after IM administration of 1.5, 3 and 6 mg/kg, increased CK and LDH values, which may be associated with muscle damage, may limit use of KTP via IM injection in lambs.   Vpliv naraščajočih odmerkov ketoprofena na biokemične in koagulacijske parametre pri jagnjetih Izvleček: Ketoprofen (KTP) je nesteroidno protivnetno zdravilo (NSAID), ki se v humani in veterinarski medicini uporablja kot sredstvo proti bolečinam, povišani temperaturi in vnetju. Čeprav se KTP pri ovcah uporablja za zdravljenje mišičnoskeletnih vnetij, endotoksemije, pljučnice, enteritisa in pri manjših kirurških posegih, kot sta odstranjevanje rogov in kastracija, ni podatkov o varnosti zdravila. Namen te študije je bil ugotoviti vpliv biokemijskih in koagulacijskih parametrov po intramuskularni (IM) aplikaciji različnih odmerkov KTP pri jagnjetih. Vrednosti aspartataminotransferaze (AST), kreatin kinaze (CK) in laktat dehidrogenaze (LDH) so se po 24 urah v primerjavi z 0 urami v vseh skupinah znatno povečale (p < 0,05). KTP ni povzročil značilnih sprememb vrednosti albumina (ALB), alanin aminotransferaze (ALT), dušika sečnine v krvi (BUN), kreatinina (CRE), CK in LDH v različnih skupinah odmerkov. Vrednost AST je bila po 24 urah pomembno višja le v skupini z odmerkom 6 mg/kg v primerjavi s skupino z odmerkom 1,5 mg/kg (p < 0,05). Čeprav znotraj posameznih skupin ni bilo statistično pomembnih razlik v vrednostih protrombinskega časa (PT), fibrinogena in D-dimerov, smo v skupini z odmerkom 6 mg/kg v 24 urah v primerjavi z uro 0 opazili znatno povečanje vrednosti aktiviranega delnega tromboplastinskega časa (aPTT) (p < 0,05). Posledično bi lahko povečane vrednosti CK in LDH (ki so lahko povezane s poškodbami mišic) omejile uporabo IM aplikacije KTP pri jagnjetih.  Ključne besede: varnost zdravil; hemostatska funkcija; hepatotoksičnost; ketoprofen; jagnjeta; nefrotoksičnost; nesteroidno protivnetno zdravilo

Publisher

University of Ljubljana

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3