Imaging evaluation of lung cancer treated with PD-1/PD-L1 inhibitors

Author:

Mohammed Nader1,Zhou Rong Rong2,Xiong Zeng1

Affiliation:

1. Department of Radiology, Xiangya Hospital, Central South University, Changsha, China

2. Department of Oncology, Xiangya Hospital, Central South University, Changsha, China

Abstract

Immunotherapy (PD-1/PD-L1 inhibitors) has attracted attention for lung cancer treatment and recasted the administration of immunotherapeutics to patients who have advanced/metastatic diseases. Whether in combination or as monotherapy, these medications have become common therapies for certain patients with lung cancer. Moreover, their usage is expected to expand widely in the future. This review aims to discuss the imaging evaluation of lung cancer response to PD-1/PD-L1 therapy with focus on new radiological criteria for immunotherapy response. Abnormal radiological responses (pseudoprogression, dissociative responses, and hyperprogression) and immune-related adverse events are also described.

Publisher

British Institute of Radiology

Subject

Radiology, Nuclear Medicine and imaging,General Medicine

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