The evolving roles of radiolabeled quinones as small molecular probes in necrotic imaging

Author:

Su Chang1,Xu Yan1

Affiliation:

1. Office of Good Clinical Practice, The Affiliated Sir Run Run Hospital of Nanjing Medical University (the Third Affiliated Hospital of Nanjing Medical University), Nanjing 211166, Jiangsu Province, P.R.China

Abstract

Necrosis plays vital roles in living organisms which is related closely with various diseases. Non-invasively necrotic imaging can be of great values in clinical decision-making, evaluation of individualized treatment responses, and prediction of patient prognosis. This narrative review will demonstrate how the evolution of quinones for necrotic imaging has been promoted by searching for their active centers. In this review, we summarized the recent developments of various quinones with the continuous simplified π-conjugated cores in necrotic imaging and speculated their possible molecular mechanisms might be attributed to their intercalations with exposed DNA in necrotic tissues. We discussed their clinical challenges of necrotic imaging with quinones and their future translation studies deserved to be explored in personalized patient treatment.

Publisher

British Institute of Radiology

Subject

Radiology, Nuclear Medicine and imaging,General Medicine

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