Affiliation:
1. Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China
Abstract
HCC is one of the most common malignant tumors. The life and health of humans are gravely threatened by HCC because of its hidden onset, high recurrence rate, poor therapeutic effect, and high mortality. It is essential to explore the particular pathological mechanisms of HCC in order to increase the rate of early diagnosis and enhance patient therapy outcomes. Recent research has demonstrated that SCUBE3 can influence HCC cell proliferation by regulating the TGFβ/PI3K/AKT/GSK3β pathway. The molecular regulatory network of HCC proliferation is improved by this research, which also offers a solid theoretical and experimental foundation for SCUBE3 as a potential new therapeutic target for HCC.
Funder
National Science and Technology Major Project
Natural Science Foundation of Chongqing
Subject
Anesthesiology and Pain Medicine,Analytical Chemistry,Anthropology,Cultural Studies,Management, Monitoring, Policy and Law,Ecology,Aquatic Science,General Chemical Engineering,Hematology,Geriatrics and Gerontology,Gerontology,Endocrinology,Endocrinology, Diabetes and Metabolism,Pollution,Waste Management and Disposal,Applied Microbiology and Biotechnology,Environmental Engineering,Aquatic Science