Abstract
Objective: Continuous inflammation at the level of the vascular endothelium plays an important role in the formation of hypertension. Diurnal blood pressure (BP) variation also is a risk factor for hypertensive target organ damage. This study planned to evaluate these inflammation processes in normotensive and hypertensive patients.
Methods: This study is observational cross-sectional cohort in-design. 151 patients with a prediagnosis of hypertension included. The patients were divided into three groups (group 1: dipper normotensive, group 2: non-dipper normotensive, group 3: dipper-hypertensive) based on the results of ambulatory blood pressure monitoring. The groups were compared in terms of systemic inflammation index (SII; platelet count×neutrophil count/lymphocyte count), neutrophil to lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and other inflammation processes.
Results: There was a significant difference between the three groups in terms of mean platelet volume (MPV) and red blood cell distribution width (RDW) levels (p=0.001 and p<0.001, respectively). A statistically significant difference was found between the groups in terms of NLR, PLR, systemic inflammation index, lymphocyte-monocyte ratio (LMR). In subgroup analysis, NLR and systemic inflammation index were similar in group 2 and group 3, but higher than in group 1 in both groups. LMR was similar in group 2 and group 3 but lower than in group 1. In subgroup analysis PLR levels were similar in group 2 and group 3 but higher than group 1 in both groups.
Conclusion: This study showed that normotensive non-dipper patients had inflammation as much as dipper hypertensive patients according to measurement of MPV, RDW systemic inflammation index, PLR, NLR levels.
Publisher
Center for Scientific Research and Development of Education
Reference20 articles.
1. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360: 1903–13.
2. Taguchi H, Kataoka M, Yanagisawa R, Kawakami T, Tamura Y, Fukuda K,et al. Platelet level as a new prognostic factor for idiopathic pulmonary arterial hypertension in the era of combination therapy. Circ J 2012; 76: 1494–500.
3. Opie LH. Hypertension, platelets, and inflammatory responses. Cardiovasc Drugs Ther 2014; 28: 291–2.
4. Surgit O, Pusuroglu H, Erturk M, Akgul O, Buturak A, Akkaya E, et al. Assessment of mean platelet volume in patients with resistant hypertension, controlled hypertension and normotensives. Eurasian J Med 2015; 47: 79–84.
5. Andronescu AM, Delcea C, Enache V, Stamate CS, Dorobanțu M. Mean platelet volume variability in young patients with non-ST elevation acute myocardial infarction. J Med Life 2014; 7: 107–13.
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