Synthesis and Bio-Evaluation of Novel N-(4-(8-Methoxy-2-Oxo-2<i>H</i>-Chromen-3-Yl) Thiazol-2-Yl) Amide Derivatives-Reference-Cited by-同舟云学术

Synthesis and Bio-Evaluation of Novel N-(4-(8-Methoxy-2-Oxo-2H-Chromen-3-Yl) Thiazol-2-Yl) Amide Derivatives

Published:2016-11 Issue: Volume:71 Page:19-28
ISSN:2299-3843
Container-title:International Letters of Chemistry, Physics and Astronomy
language:
Short-container-title:ILCPA

Author:

Shah Nilay¹,Patel Pineshkumar N.²,Rajani Dhanji³,Karia Denish C.⁴

Affiliation:

1. Cadila Health Care Pvt. Ltd

2. Huntsman International India Pvt. Ltd

3. Microcare Laboratories and Tuberculosis Research Center

4. Patel J D K Davolwala Science College

Abstract

In present work, novel derivatives of substituted N-(4-(8-methoxy-2-oxo-2H-chromen-3-yl) thiazol-2-yl) amide have been synthesized. The solvent free reaction of 2-Hydroxy-3-methoxybenzaldehyde with Ethyl acetoacetate in presence of Piperidine catalyst produces 3-acetyl-8-methoxy-2H-chromen-2-one (C). Compound C was α- brominated using CuBr2and subsequently cyclized using Thiourea to produce 3-(2-aminothiazol-4-yl)-8-methoxy-2H-chromen-2-one as main scaffold (E). This scaffold E was finally reacted with different Acid chloride to isolate title compound derivatives. The chemical structures of synthesized compounds were confirmed by1H-NMR, FT-IR and Mass spectral/LCMS analysis. The synthesized compounds were screened for potential Antimicrobial, Antifungal and Antimalarial activity.

Publisher

SciPress Ltd

Subject

Psychiatry and Mental health,Neuropsychology and Physiological Psychology

Link

https://www.scipress.com/ILCPA.71.19.pdf

Reference24 articles.

1. D. Davyt, G. Serra, Thiazole and oxazole alkaloids: Isolation and synthesis, Mar. Drugs. 8 (2010) 2755–2780.

2. A. Geronikakil, G. Theophilidis, Synthesis of 2-(aminoacetylamino) thiazole derivatives and comparison of their local anaesthetic activity by the method of action potential, European journal of medicinal chemistry. 2 (1992) 709–716.

3. M. Li, Y. Sim, S.W. Ham, Discovery of 2-aminothiazole derivatives as antitumor agents, Bull. Korean Chem. Soc. 31 (2010) 1463–1464.

4. N. Singh et al., Synthesis and antimicrobial activity of some novel 2-amino thiazole derivatives, J. Chem. Pharm. Res. 2(3) (2010) 691–698.

5. K. Prakasha, Design, synthesis and antimicrobial screening of amino acids conjugated 2-amino-4-arylthiazole derivatives, Int. J. Pharm. Pharm. Sci. 3 (2011) 120-125.