Affiliation:
1. Shree M&N Virani Science Collage
Abstract
A convenient synthesis of substituted Pyrazolo[1,5-a]pyrimidine was carried out by the reaction of different ketene dithioacetals with different aromatic amine in isopropanol in the presence of potassium carbonate. The newly synthesized compound were characterized by1H NMR, IR, Mass and screened for their antimicrobial activity against various strains of bacteria and fungi. From the synthesized different NCEs, compounds 8a, 8d and 8e are broad spectrum drug which can inhibit the growth of gram positive, gram negative bacteria and fungi.
Subject
Psychiatry and Mental health,Neuropsychology and Physiological Psychology
Reference26 articles.
1. D. Pansuriya, K. Menpara, N. Kachhadiya, J. Menpara, and K. Ladva, Synthesis, Characterization & Biological evaluation of sulfonamide analogue of Tetrazolo[1, 5-a] pyrimidines, J. Appl. Chem., vol. 3, no. 6, p.2335–2342, (2014).
2. J. A. ALEXANDER, G. P. WHEELER, D. D. HILL, and H. P. MORRIS, EFFECTS OF 4-HYDROXYPYRAZOL0(3, 4-d)PYRIMIDINE UPON THE CATABOLISM OF PURINES BY VARIOUS TISSUES OF THE RAT AND UPON THE RATE OF GROWTH OF MORRIS 5123-C HEPATOMA, Biochem. Pharmacol., vol. 15, p.881–889, (1966).
3. B. Elion, S. Callahan, H. Nathan, S. Biebek, R. W. Rundles, and G. H. Hikhings, POTENTIATION BY INHIBITION OF DRUG DEGRADATION: 6-SUBSTITUTED PURINES AND XANTHTNE OXIDASE, Biochem. Pharmacol., vol. 12, p.85–93, (1963).
4. R. A. Earl, R. J. Pugmire, G. R. Revankar, and eroy B. Townsend, A Chemical and Carbon- 13 Nuclear Magnetic Resonance Reinvestigation of the N-Methyl Isomers Obtained by Direct Methylation of 5-Amino-3, 4- dicyanopyrazole and the Synthesis of Certain Pyrazolo[ 3, 4-d]pyrimidines, J. Org. Chem., vol. 40, no. 12, p.1822–1828, (1975).
5. T. Novinson, B. Bhooshan, T. Okabe, G. R. Revankar, R. K. Robins, K. Senga, and H. R. Wilson, Novel Heterocyclic Nitrofurfural Hydrazones. In Vivo Antitrypanosomal Activity, J. Med. Chem., vol. 19, no. 4, p.512–516, (1976).
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