Progress in research on childhood T-cell acute lymphocytic leukemia, Notch1 signaling pathway, and its inhibitors: A review

Abstract

Childhood leukemia is a cancer seriously threatening children’s life in China. The treatment of T-cell acute lymphocytic leukemia (T-ALL) is extremely difficult due to its early infiltration, poor sensitivity to chemotherapy, and susceptibility to drug resistance. At the same time, the traditional intensive chemotherapy regimens cause great damage to children, so it is highly important to search for the targeted drugs and develop precise individualized treatment of child patients. The Notch signaling pathway is involved the pathogenesis of T-ALL, and there are activating mutations in the NOTCH1 gene in more than 50% of human T-ALLs. In this review, we summarize the progress in research on T-ALL and Notch1 signaling pathway inhibitors, so as to provide a theoretical basis for the clinical treatment of T-ALL.