Reconstruction of intestinal microecology of Type 2 diabetes by Fecal Microbiota Transplantation: Why and How

Abstract

Type 2 diabetes (T2D) is a chronic metabolic disease characterized by hyperglycemia due to insulin resistant. Mounting evidence has correlated T2D to alterations in the composition of gut microbiota. Accordingly, targeting the gut microbiota has become an emerging strategy to benefit the T2D management. To get a better insight into the rationale for targeting gut microbiota in T2D treatment, we herein reviewed the change of gut microbiota composition in T2D, factors shaping gut microbiota, and potential mechanisms about contribution of gut microbiota to T2D pathogenesis.At present, it has become possible to use intestinal microorganism capsules, bacteria liquid and other preparations to carry out FMT for the treatment and intervention of T2D with insulin resistance and immune-mediated Type 1 diabetes(T1D).