Non-Convulsive Status Epilepticus as a Manifestation of Methotrexate-Induced Leukoencephalopathy

Abstract

Methotrexate (MTX) is an anti-metabolite used in the treatment of leukemia and autoimmune disease. Careful observation of MTX concentration should be performed as side effects such as seizure, headache, limb paralysis, and confusion are found in MTX-induced leukoencephalopathy. To our knowledge, there was no reported case of non-convulsive status epilepticus as a manifestation of MTX-induced leukoencephalopathy in South Korea. Here, we report a 54-year-old patient that was diagnosed with non-convulsive status epilepticus after long-term use of MTX.