Preparation of sorbents for solid-phase extraction of salicylic acid from aqueous solutions

Abstract

Salicylic acid and its derivatives are widely used in medicine and pharmacy as antipyretic, antirheumatic, anti-inflammatory and analgesic drugs for external and internal use. The development of methods for the quantitation of salicylic acid in multicomponent samples using selective methods of sample preparation is an important problem in quality drug control. The aim of the study was to obtain sorbents based on ethyl cellulose for solid-phase extraction of salicylic acid from aqueous solutions. As a result of the study, a method for obtaining a sorbent for solid-phase salicylic acid from aqueous solutions was proposed. The IR spectroscopy of the obtained sorbent samples did not establish significant structural differences between ethylcellulose and the obtained sorbents. Optimal concentrations of ethylcellulose and salicylic acid solutions in the reaction mixture for obtaining the sorbent with a maximum value of sorption capacity of 93.5 g/g of sorbent were revealed. The method for the quantitation of salicylic acid from aqueous solutions with the use of the obtained sorbent was proposed. Metrological estimation of salicylic acid quantitation with the help of the obtained sorbent for solid-phase extraction was carried out.