Standardization of pectoral species no. 2: current state and prospects

Abstract

Nowadays, diseases of the respiratory system are a common problem for national and global healthcare. The drugs of synthetic and natural origin, intended for the prevention and treatment of these diseases, are available on the pharmaceutical market. The latter are mainly represented by herbal medicinal products, among which mixture herbal products occupy a special place. Pectoral species No. 2 is a multicomponent herbal medicinal products used for diseases of the upper respiratory tract, it includes coltsfoot leaves (40%), plantain leaves (30%), and licorice roots (30%). It is produced in the form of powder and is dispensed in packs and filter sachet. On the basis of information and analytical research, some approaches to the standardization of pectoral species No. 2 are developed in this study. Currently, the infusion is the main dosage form of pectoral species No. 2; water-soluble biologically active compounds are fully extracted by water and are responsible for the manifested pharmacological effects of pectoral species No. 2 (polysaccharides and triterpene compounds). The development of modern regulatory documentation for complex herbal preparations (mixture herbal products) should be carried out taking into account scientifically based data and harmonized requirements. Additional experimental studies are required to substantiate the indicators and standards of identity and good quality of pectoral species No. 2. Modern regulatory documentation for pharmaceutical substances of plant origin and mixture herbal products made of them (including pectoral species No. 2) should include sections that take into account the principle of raw material-to-drug standardization and methods that can be used in research laboratories with various material and technical support.