Humin-containing dosage form: technology, application prospects

Abstract

This article is devoted to the development of technology and methods for assessing the quality of suppositories containing humic acids of low-mineralized silt sulfide mud. The quality standards of the studied medicinal product were established and its stability during storage was determined. The quantitative determination of humic acids in aqueous solutions was determined by the spectrophotometric method. When studying the technological indicators of the suppositories, the following indicators were taken into account: description, average weight, melting temperature and time of complete deformation. The results of visual control showed that the appearance of the suppositories did not change during one year of storage. However, some white plaque and color heterogeneity appeared with the increase of the shelf life up to 1.5 years. The amount of the active substance during the storage of suppositories changed slightly and did not exceed the permissible content standards. The melting point value did not exceed 36 C, and its decrease was not observed. The time of complete deformation of the suppositories did not exceed 15 minutes and was 5-6 minutes during storage. The average weight of suppositories during storage remained stable. The study allows to conclude that the proposed suppositories are stable for 12 months and the preliminary shelf life of suppositories is 1 year. The conducted chemical and pharmaceutical studies scientifically substantiate the expediency of using medicines with humic acids that demonstrate antioxidant and anti-inflammatory properties. This will expand the range of domestic medicines with the given spectrum of therapeutic action.