Features of protein glycosylation in multiple sclerosis

Abstract

The article presents an analytical review of the published data on the features of protein glycosylation in multiple sclerosis (MS). The search in the PubMed database with the keywords "multiple sclerosis, glycosylation", for the period of 2012-2022, resulted in 12 sources presenting the studies on N-glycosylated plasma proteins and immunoglobulins G in multiple sclerosis, clinically isolated syndrome, neuromyelitis optica spectrum disorders and meningitis of viral etiology in patients' cerebrospinal fluid and blood serum. The studies revealed specific changes in glycoproteins in multiple sclerosis. Glycome changes correlated with the age and sex of patients, with the clinical form of the disease, as well as with the degree of disability on the EDSS scale. These findings can contribute to the early diagnosis of MS, the definition of the form of the disease and its course prediction. Given the diversity of the glycome expression, the differences in its modifications in different environments (serum and blood plasma, cerebrospinal fluid), as well as the variety of approaches to its study (many quantitative and qualitative biochemical methods), there is a prospect of further search for markers and predictors of the course of multiple sclerosis.