Can the De Ritis Ratio (AST/ALT) be used to predict colon cancer stages?

Abstract

Purpose: The De Ritis ratio (Aspartat transaminase/alanine transaminase) is a critical prognostic factor for some kinds of malignant tumors. Nevertheless, the De Ritis ratio’s prognostic value in preoperative colon cancer staging is unclear. The purpose of this research was to determine the De Ritis ratio in colon cancer and to determine its prognostic significance for colon cancer. Materials and Methods: The clinicopathological data of 271 individuals with malign colon cancer were analyzed retrospectively, from January 2010 to January 2018 at a single center. The relationship between the De Ritis coefficient and clinicopathological findings in patients were evaluated before treatment. To compare groups, the Mann-Whitney U test and the Kruskal Wallis test were performed. Results: The results indicated that there were no statistically significant differences between the groups, in terms of pre-treatment De Ritis ratio assessment as a staging, localization, tumor diameter, lymph node metastasis, age and overall survival. However, differences in T staging between groups of male participants were shown to be statistically significant. Conclusions: The De Ritis ratio evaluated before to treatment was not an independent variable a prognostic factor in the diagnosis and staging of colon cancer. However, future study may demonstrate the significance of the De Ritis ratio with more participants.