Soluble P2X7 Receptor Plasma Levels in Obese Subjects before and after Weight Loss via Bariatric Surgery
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Published:2023-11-25
Issue:23
Volume:24
Page:16741
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ISSN:1422-0067
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Container-title:International Journal of Molecular Sciences
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language:en
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Short-container-title:IJMS
Author:
Di Vincenzo Angelo1, Granzotto Marnie1ORCID, Graziani Andrea1ORCID, Crescenzi Marika1, Foletto Mirto2ORCID, Prevedello Luca2, Capone Federico1ORCID, Vettor Roberto1ORCID, Rossato Marco1ORCID
Affiliation:
1. Clinica Medica 3, Department of Medicine—DIMED, University Hospital of Padova, 35128 Padua, Italy 2. Bariatric Surgery Unit, University Hospital of Padova, 35128 Padua, Italy
Abstract
Obesity is a systemic disease frequently associated with important complications such as type 2 diabetes and cardiovascular diseases. It has also been proven that obesity is a disease associated with chronic low-grade systemic inflammation and that weight loss improves this low-grade chronic inflammatory condition. The P2X7 purinergic receptor (P2X7R), belonging to the family of the receptors for extracellular ATP, is a main player in inflammation, activating inflammasome and pro-inflammatory cytokine production. In this study, we evaluated the plasma levels of soluble P2X7R (sP2X7R) measured in a group of obese patients before and one year after bariatric surgery. Furthermore, we evaluated the relation of sP2X7R to inflammatory marker plasma levels. We enrolled 15 obese patients who underwent laparoscopic sleeve gastrectomy, evaluating anthropometric parameters (weight, height, BMI and waist circumference) before and after surgery. Moreover, we measured the plasma levels of inflammatory markers (CRP, TNFα and IL-6) before and after weight loss via bariatric surgery. The results of our study show that one year after bariatric surgery, obese patients significantly decrease body weight with a significant decrease in CRP, TNF-alfa and IL-6 plasma levels. Similarly, after weight loss, obese subjects showed a significant reduction in sP2X7R plasma levels. Moreover, before surgery, plasma levels of sP2X7R were inversely related with those of CRP, TNF-alfa and IL-6. Given the role of P2X7R in inflammation, we hypothesized that, in obese subjects, sP2X7R could represent a possible marker of chronic low-grade inflammation, hypothesizing a possible role as a mediator of obesity complications.
Funder
PRIN—Research Projects of National Relevance—by the Italian Minister of University SAFAS Group SpA, Altavilla, Vicenza, Italy
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference35 articles.
1. Contemporary medical, device, and surgical therapies for obesity in adults;Perdomo;Lancet,2023 2. Jorquera, G., Russell, J., Monsalves-Álvarez, M., Cruz, G., Valladares-Ide, D., Basualto-Alarcón, C., Barrientos, G., Estrada, M., and Llanos, P. (2021). NLRP3 inflammasome: Potential role in obesity related low-grade inflammation and insulin resistance in skeletal muscle. Int. J. Mol. Sci., 22. 3. Review article: Adipocytokines and insulin resistance;Vettor;Aliment. Pharmacol. Ther.,2005 4. Rossato, M., Favaretto, F., Granzotto, M., Crescenzi, M., Boscaro, A., Di Vincenzo, A., Capone, F., Dalla Nora, E., Zabeo, E., and Vettor, R. (2022). Molecular and pharmacological evidence for the expression of multiple functional P2 purinergic receptors in human adipocytes. Molecules, 27. 5. Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle;Bouzakri;Mol. Endocrinol.,2006
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