Current Treatment Options for REM Sleep Behaviour Disorder

Author:

Jiménez-Jiménez Félix JavierORCID,Alonso-Navarro HortensiaORCID,García-Martín ElenaORCID,Agúndez José A. G.

Abstract

The symptomatic treatment of REM sleep behaviour disorder (RBD) is very important to prevent sleep-related falls and/or injuries. Though clonazepam and melatonin are usually considered the first-line symptomatic therapy for RBD, their efficiency has not been proven by randomized clinical trials. The role of dopamine agonists in improving RBD symptoms is controversial, and rivastigmine, memantine, 5-hydroxytryptophan, and the herbal medicine yokukansan have shown some degree of efficacy in short- and medium-term randomized clinical trials involving a low number of patients. The development of potential preventive therapies against the phenoconversion of isolated RBD to synucleinopathies should be another important aim of RBD therapy. The design of long-term, multicentre, randomized, placebo-controlled clinical trials involving a large number of patients diagnosed with isolated RBD with polysomnographic confirmation, directed towards both symptomatic and preventive therapy for RBD, is warranted.

Funder

Instituto de Salud Carlos III

Junta de Extremadura, Mérida, Spain

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

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