A New Method for the Synthesis of 1-(1-Isocyanoethyl)adamantane-Reference-Cited by-同舟云学术

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A New Method for the Synthesis of 1-(1-Isocyanoethyl)adamantane

Published:2024-06-06 Issue:2 Volume:2024 Page:M1833
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Pitushkin Dmitry¹²^ORCID,Butov Gennady²^ORCID

Affiliation:

1. Department of Organic Chemistry, Volgograd State Technical University, Volgograd 400005, Russia

2. Department of Chemistry, Technology and Equipment of Chemical Industry, Volzhsky Polytechnic Institute (Branch), Volgograd State Technical University, Volzhsky 404121, Russia

Abstract

A novel single-step method has been developed for the synthesis of 1-(1-isocyanoethyl)adamantane from 1-(1-adamantylethyl)amine, chloroform, and t-BuOK, in a dichloromethane/tert-butanol (1:1) medium, yielding 92%, which is 27% higher compared to the known method, without the use of highly toxic compounds. The product was characterized using 1H and 13C NMR spectroscopy, GC-MS, and elemental analysis.

Funder

Russian Science Foundation

Publisher

MDPI AG

Link

https://www.mdpi.com/1422-8599/2024/2/M1833/pdf

Reference14 articles.

1. Multicomponent Reactions of Convertible Isonitriles;Pirrung;J. Org. Chem.,2009

2. Gokel, G.W. (1971). Organic Chemistry, Elsevier.

3. Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry;Chem. Rev.,2006

4. Multicomponent Reactions with Isocyanides;Ugi;Angew. Chem. Int. Ed. Engl.,2000

5. An Efficient Passerini Tetrazole Reaction (PT-3CR);Chandgude;Green Chem.,2016

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