Possible Etiological Factors for the Development of Molar Incisor Hypomineralization (MIH) in Austrian Children

Abstract

Background: Molar incisor hypomineralization (MIH) is a developmental enamel defect that primarily affects the first permanent molars and sometimes the incisors. Its increasing prevalence worldwide has raised clinical concerns, yet its exact cause remains unknown. This study aimed to assess potential factors influencing MIH development by analyzing the medical history of children aged 6 to 12 years using a questionnaire. Methods: This study included 100 children aged 6–12 years diagnosed with MIH during dental examination, and 100 age-matched children in the non-MIH (healthy) group from the Department of Pediatric Dentistry, University Clinic of Dentistry, Medical University of Vienna. The parents of the participants completed a two-page questionnaire regarding possible etiological factors of MIH. Results: The data analysis involved 100 children with MIH (mean age 8.5; ±1.3; 52% female) and 100 children in the healthy group (mean age 9.2; ±1.3; 42% female). The optimized binary logistic regression analysis revealed a significant association between MIH development and cesarean-section delivery (OR = 3; CI = [1.5–6.2]) and sixth disease (roseola) (OR = 3.5; CI = [1.5–8.0]). Conclusions: This study suggests that cesarean-section delivery and sixth disease (roseola) might increase the likelihood of MIH development in children.