Abstract
Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications.
Funder
Higher Education Commision, Pakistan
Subject
Electrical and Electronic Engineering,Biochemistry,Instrumentation,Atomic and Molecular Physics, and Optics,Analytical Chemistry
Reference176 articles.
1. Interleukin 6;Kishimoto,2015
2. Interleukin-6: A regulator of plasma protein gene expression in hepatic and non-hepatic tissues;Sehgal;Mol. Biol. Med.,1990
3. Biology of multifunctional cytokines: IL-6 and related molecules (IL 1 & TNF);Akira;FASEB J.,1990
4. Biological and clinical aspects of interleukin 6
5. Interleukin-6: An Overview
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