Review of the Potential of Probiotics in Disease Treatment: Mechanisms, Engineering, and Applications

Author:

Liu Mingkang1,Chen Jinjin2,Dharmasiddhi Ida Putu Wiweka2,Chen Shiyi1,Liu Yilan2,Liu Hongmei1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China

2. Department of Chemical Engineering, University of Waterloo, 200 University Avenue West Waterloo, Waterloo, ON N2L 3G1, Canada

Abstract

Probiotics, living microorganisms with demonstrated health benefits when administered in sufficient quantities, have a rich history as dietary supplements to benefit human health. Recently, understanding of their mechanisms in the gastrointestinal tract has prompted exploration of probiotics in treating human diseases. However, the effective and precise delivery of probiotics remains a significant challenge in therapeutic applications. Here, we review the mechanisms of action of probiotics in human health and the most advanced strategies for efficient probiotic delivery. We also discuss the potential applications of engineered probiotics in disease treatment. This review contributes insights into the evolving landscape of probiotic research for therapeutic applications.

Funder

Shenzhen Science and Technology Innovation Commission, China

Publisher

MDPI AG

Subject

Process Chemistry and Technology,Chemical Engineering (miscellaneous),Bioengineering

Reference77 articles.

1. The probiotic century: Historical and current perspectives;Shortt;Trends Food Sci. Technol.,1999

2. Who, F. (2001, January 1–4). Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Proceedings of the Report of a Joint FAO/WHO Expert Consultation, Córdoba, Argentina.

3. Chemically and biologically engineered bacteria-based delivery systems for emerging diagnosis and advanced therapy;Li;Adv. Mater.,2021

4. Next-generation probiotics: A promising approach towards designing personalized medicine;Singh;Crit. Rev. Microbiol.,2021

5. Surface-modified bacteria: Synthesis, functionalization and biomedical applications;Lin;Chem. Soc. Rev.,2023

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3