Recent Developments in Biopolymer-Based Hydrogels for Tissue Engineering Applications

Author:

Hama Rikako12,Ulziibayar Anudari1ORCID,Reinhardt James W.1ORCID,Watanabe Tatsuya1,Kelly John1,Shinoka Toshiharu134ORCID

Affiliation:

1. Center for Regenerative Medicine, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA

2. Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-Cho, Koganei 184-8588, Japan

3. Department of Cardiothoracic Surgery, The Heart Center, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, USA

4. Department of Surgery, Cardiovascular Tissue Engineering Program, Ohio State University, Columbus, OH 43210, USA

Abstract

Hydrogels are being investigated for their application in inducing the regeneration of various tissues, and suitable conditions for each tissue are becoming more apparent. Conditions such as the mechanical properties, degradation period, degradation mechanism, and cell affinity can be tailored by changing the molecular structure, especially in the case of polymers. Furthermore, many high-functional hydrogels with drug delivery systems (DDSs), in which drugs or bioactive substances are contained in controlled hydrogels, have been reported. This review focuses on the molecular design and function of biopolymer-based hydrogels and introduces recent developments in functional hydrogels for clinical applications.

Funder

WISE Program

Gunze Limited

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

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