Effect of Intravenous Dexamethasone Dose on the Occurrence of Rebound Pain after Axillary Plexus Block in Ambulatory Surgery

Author:

Touil Nassim1ORCID,Pavlopoulou Athanassia1,Delande Simon1,Geradon Pierre1,Barbier Olivier2,Libouton Xavier2ORCID,Lavand’homme Patricia1

Affiliation:

1. Department of Anaesthesiology, Cliniques Universitaires Saint-Luc, Catholic University of Louvain, B-1200 Brussels, Belgium

2. Department of Orthopaedic Surgery, Cliniques Universitaires Saint-Luc, Catholic University of Louvain, B-1200 Brussels, Belgium

Abstract

Rebound pain (RP) remains a challenge in ambulatory surgery, characterized by severe pain upon resolution of a peripheral nerve block (PNB). Intravenous (IV) administration of Dexamethasone (DEXA) potentiates PNB analgesic effect and reduces RP incidence although preventive effective dose remains undetermined. This retrospective analysis evaluates the preventive effect of IV DEXA on RP in outpatients undergoing upper limb surgery under axillary block. DEXA was divided into high (HD > 0.1 mg/kg) or low (LD < 0.1 mg/kg) doses. RP was defined as severe pain (NRS ≥ 7/10) within 24 h of PNB resolution. DEXA HD and LD patients were matched with control patients without DEXA (n = 55) from a previous randomized controlled study. Records of 118 DEXA patients were analyzed (DEXA dose ranged from 0.05 to 0.12 mg/kg). Intraoperative IV DEXA was associated with a significant reduction of the pain felt when PNB wore off as well as to a significant reduction of RP incidence (n = 27/118, 23% vs. 47% in controls, p = 0.002) with no effect related to the dose administered (p = 0.053). Our results support the administration of intraoperative DEXA as a preventive measure to reduce the occurrence of RP.

Publisher

MDPI AG

Subject

General Medicine

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