The Endocannabinoid System: A Target for Cancer Treatment

Author:

Laezza Chiara,Pagano Cristina,Navarra Giovanna,Pastorino Olga,Proto Maria ChiaraORCID,Fiore DonatellaORCID,Piscopo ChiaraORCID,Gazzerro Patrizia,Bifulco Maurizio

Abstract

In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.

Funder

AIRC

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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