Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021

Novel Bioactive Natural Products from Marine-Derived Penicillium Fungi: A Review (2021–2023)

Published:2024-04-23 Issue:5 Volume:22 Page:191
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Lv Fang¹,Zeng Yanbo²^ORCID

Affiliation:

1. Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China

2. Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China

Abstract

Marine-derived Penicillium fungi are productive sources of structurally unique and diverse bioactive secondary metabolites, representing a hot topic in natural product research. This review describes structural diversity, bioactivities and statistical research of 452 new natural products from marine-derived Penicillium fungi covering 2021 to 2023. Sediments are the main sources of marine-derived Penicillium fungi for producing nearly 56% new natural products. Polyketides, alkaloids, and terpenoids displayed diverse biological activities and are the major contributors to antibacterial activity, cytotoxicity, anti-inflammatory and enzyme inhibitory capacities. Polyketides had higher proportions of new bioactive compounds in new compounds than other chemical classes. The characteristics of studies in recent years are presented.

Funder

Natural Science Foundation of Hainan

National Natural Science Foundation of China

Financial Fund of the Ministry of Agriculture and Rural Affairs, China

Publisher

MDPI AG

Link

https://www.mdpi.com/1660-3397/22/5/191/pdf

Reference126 articles.

1. Noman, E., Al-Shaibani, M.M., Bakhrebah, M.A., Almoheer, R., Al-Sahari, M., Al-Gheethi, A., Mohamed, R.M.S.R., Almulaiky, Y.Q., and Abdulaal, W.H. (2021). Potential of anti-cancer activity of secondary metabolic products from marine fungi. J. Fungi, 7.

2. Shin, H.J. (2020). Natural products from marine fungi. Mar. Drugs, 18.

3. Structures and bioactivities of secondary metabolites from Penicillium genus since 2010;Zhang;Fitoterapia,2022

4. Liu, S., Su, M.Z., Song, S.J., and Jung, J.H. (2017). Marine-derived Penicillium species as producers of cytotoxic metabolites. Mar. Drugs, 15.

5. ‘Marine fungi’ and ‘marine-derived fungi’ in natural product chemistry research: Toward a new consensual definition;Pang;Fungal Biol. Rev.,2016