Vascular Health of Females with History of Assisted Reproductive Technology

Author:

Li Pengzhu1,Langer Magdalena1,Vilsmaier Theresa2ORCID,Kramer Marie1,Sciuk Franziska1,Kolbinger Brenda12,Jakob André1ORCID,Rogenhofer Nina2,Dalla-Pozza Robert1,Thaler Christian2,Haas Nikolaus Alexander1,Oberhoffer Felix Sebastian1

Affiliation:

1. Division of Pediatric Cardiology and Intensive Care, University Hospital, LMU Munich, 81377 Munich, Germany

2. Division of Gynecological Endocrinology and Reproductive Medicine, Department of Gynecology and Obstetrics, University Hospital, LMU Munich, 81377 Munich, Germany

Abstract

The use of assisted reproductive technologies (ART) for the treatment of infertility is gaining popularity. Limited data on the overall vascular health of females with history of ART are available. This pilot study aimed to investigate the overall vascular health of females with history of ART compared to individuals who conceived spontaneously. The assessment of overall vascular health included the measurement of brachial blood pressure, central blood pressure, and pulse wave velocity, as well as the evaluation of the arterial stiffness and carotid intima-media thickness (cIMT) of the common carotid arteries. Conventional blood lipids including lipoprotein a (Lp(a)) were also determined. In total, 45 females with history of ART and 52 females who conceived spontaneously were included (mean age: 47.72 ± 5.96 years vs. 46.84 ± 7.43 years, p = 0.525). An initial comparison revealed a significantly higher prevalence of elevated Lp(a) in ART females (p = 0.011). However, after multiple comparison correction, the significant result disappeared (p = 0.132). Within the cohort of ART females, no significantly higher cardiovascular risk was detected regarding vascular function. The potentially higher prevalence of elevated Lp(a) in ART females must be further investigated in future studies, as it might contribute to the impaired reproductive process in this cohort.

Funder

the Deutsche Forschungsgemeinschaft

Munich Clinician Scientist Program (MCSP) of LMU Munich

Publisher

MDPI AG

Reference58 articles.

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4. Adamson, G.D., Zegers-Hochschild, F., Dyer, S., Chambers, G., De Mouzon, J., Ishihara, O., Kupka, M., Banker, M., Jwa, S.C., and Elgindy, E. (2022, January 3–6). World Report on Assisted Reproductive Technology, 2018. Proceedings of the 38th Hybrid Annual Meeting of the ESHRE, Milan, Italy.

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