Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I-Reference-Cited by-同舟云学术

Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I

Published:2023-02-28 Issue:5 Volume:16 Page:1971
ISSN:1996-1944
Container-title:Materials
language:en
Short-container-title:Materials

Author:

Kalbarczyk Marta¹²,Szcześ Aleksandra¹^ORCID,Belcarz Anna³^ORCID,Kazimierczak Paulina⁴^ORCID,May Zoltan⁵

Affiliation:

1. Department of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, 20-031 Lublin, Poland

2. Department of Electrical Engineering, Lublin University of Technology, 20-618 Lublin, Poland

3. Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin, 20-093 Lublin, Poland

4. Independent Unit of Tissue Engineering and Regenerative Medicine, Medical University of Lublin, 20-093 Lublin, Poland

5. Plasma Chemistry Research Group, Institute of Materials and Environmental Sciences, Research Centre for Natural Sciences, Magyar Tudósok krt. 2, 1117 Budapest, Hungary

Abstract

In this study, calcium phosphate materials were obtained via a simple, eco-friendly wet synthesis method using hen eggshells as a calcium source. It was shown that Zn ions were successfully incorporated into hydroxyapatite (HA). The obtained ceramic composition depends on the zinc content. When doped with 10 mol % of Zn, in addition to HA and Zn-doped HA, DCPD (dicalcium phosphate dihydrate) appeared and its content increased with the increase in Zn concentration. All doped HA materials exhibited antimicrobial activity against S. aureus and E. coli. Nevertheless, fabricated samples significantly decreased preosteoblast (MC3T3-E1 Subclone 4) viability in vitro, exerting a cytotoxic effect which probably resulted from their high ionic reactivity.

Publisher

MDPI AG

Subject

General Materials Science

Link

https://www.mdpi.com/1996-1944/16/5/1971/pdf

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