Biocompatibility and Degradation of Fe-Mn-5Si Alloy after Equal-Channel Angular Pressing: In Vitro and In Vivo Study-Reference-Cited by-同舟云学术

Biocompatibility and Degradation of Fe-Mn-5Si Alloy after Equal-Channel Angular Pressing: In Vitro and In Vivo Study

Published:2023-08-25 Issue:17 Volume:13 Page:9628
ISSN:2076-3417
Container-title:Applied Sciences
language:en
Short-container-title:Applied Sciences

Author:

Rybalchenko Olga¹^ORCID,Anisimova Natalia¹²³^ORCID,Martynenko Natalia¹^ORCID,Rybalchenko Georgy⁴,Belyakov Andrey⁵^ORCID,Shchetinin Igor¹⁶,Lukyanova Elena¹,Chernogorova Olga¹,Raab Arseniy⁷^ORCID,Pashintseva Natalia⁸,Kornyushenkov Evgeny²⁸,Babayeva Gulalek²⁹^ORCID,Sokolova Darina²⁹^ORCID,Kiselevskiy Mikhail²³,Dobatkin Sergey¹

Affiliation:

1. A.A. Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences, 119334 Moscow, Russia

2. N.N. Blokhin National Medical Research Center of Oncology (N.N. Blokhin NMRCO) of the Ministry of Health of the Russian Federation, 115478 Moscow, Russia

3. Center for Biomedical Engineering, National University of Science and Technology “MISIS”, 119049 Moscow, Russia

4. P.N. Lebedev Physical Institute of the Russian Academy of Sciences, 119991 Moscow, Russia

5. Laboratory of Mechanical Properties of Nanostructured Materials and Superalloys, Belgorod State University, 308015 Belgorod, Russia

6. Department of Physical Materials Science, National University of Science and Technology “MISIS”, 119049 Moscow, Russia

7. Institute of Physics of Advanced Materials, Ufa University of Science and Technology, 450000 Ufa, Russia

8. Limited Liability Company “Veterinary Oncological Scientific Center”, 115211 Moscow, Russia

9. Research Institute of Molecular and Cellular Medicine, RUDN University, 117198 Moscow, Russia

Abstract

An attempt to improve the functional characteristics of a degradable Fe-Mn-5Si shape memory alloy by means of structure refinement by equal-channel angular pressing (ECAP) was made. In the course of ECAP, an austenitic ultrafine-grained structure was obtained. In shear bands with a thickness of 301 ± 31 nm, twins 11 ± 1 nm in size were formed. Due to the resulting structure, the tensile strength was doubled up to 1419 MPa, and the yield strength was increased up to 1352 MPa, four times higher compared with the annealed state. Dynamic indentation tests revealed a decrease in Young’s modulus by more than 2.5 times after ECAP compared to values measured in the annealed state. The results of the study of hemolytic and cytotoxic activity in vitro, as well as the local and systemic reactivity of the body of laboratory animals after implantation of the test samples indicate the biocompatibility of the alloy after ECAP. Biocompatibility, high specific strength and low modulus of elasticity open prospects for Fe-Mn-5Si alloy after ECAP to be used for the production of degradable implants that can effectively provide the fastening function in osteoreconstruction.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

Link

https://www.mdpi.com/2076-3417/13/17/9628/pdf

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