Abstract
The absence of awareness of fungal diseases as part of the differential diagnosis in at-risk populations has severe consequences. Here, we show how the active role of laboratories can improve patients’ survival. Recently, major advances have been made in non-culture-based assays for fungal diseases, improving accuracy and turnaround time. Furthermore, with the introduction of proficiency control systems, laboratories are an easily monitored environment with good analytical accuracy. Diagnostic packages for opportunistic infections can overcome many deficiencies caused by the absence of awareness. In Guatemala, to make diagnosis accessible, we set up a diagnostic laboratory hub (DLH) providing screening for cryptococcosis, histoplasmosis and tuberculosis to a network of 13 healthcare facilities attending people living with HIV (PLWHIV). In two years, we screened 2127 newly HIV-diagnosed patients. The frequency of opportunistic infections was 21%, rising to 30.3% in patients with advanced HIV disease (<200 CD4); 8.1% of these patients had more than one infection. With the implementation of this diagnostic package, mortality decreased by 7%, a key goal of many public health interventions. Screening for serious infection in high-risk populations can partially overcome training or experiential deficiencies among clinicians for life-threatening fungal diseases.
Funder
Global Action for Fungal Infections
JYLAG
Subject
Plant Science,Ecology, Evolution, Behavior and Systematics,Microbiology (medical)
Reference32 articles.
1. Kahneman, D., Sibony, O., and Sunstein, C.R. (2021). Noise: A Flaw in Judgment, Little, Brown.
2. The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin;Hoenigl;Drugs,2021
3. World Health Organization (2022). WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action.
4. Tracing the Evolutionary History and Global Expansion of Candida Auris Using Population Genomic Analyses;Chow;Mbio,2020
5. Candida Auris: Epidemiological Situation, Laboratory Capacity and Preparedness in the European Union and European Economic Area*, January 2018 to May 2019;Plachouras;Eurosurveillance,2020
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