Antibacterial Activity of Lysimachia nummularia L. in Oro-Dental Diseases
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Published:2023-06-05
Issue:11
Volume:13
Page:6830
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ISSN:2076-3417
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Container-title:Applied Sciences
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language:en
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Short-container-title:Applied Sciences
Author:
Suciu Felicia1ORCID, Stoicescu Iuliana2ORCID, Lupu Elena Carmen3ORCID, Popescu Antoanela4ORCID, Roșca Adrian Cosmin1, Roncea Florentina Nicoleta5ORCID, Dumitrescu Denisa-Elena6ORCID, Badea Victoria7, Badea Florin Ciprian8
Affiliation:
1. Department of Analysis and Quality Control of Drugs, Faculty of Pharmacy, “Ovidius” University of Constanta, 900470 Constanta, Romania 2. Department of Chemistry and Quality Control of Drugs, Faculty of Pharmacy, “Ovidius” University of Constanta, 900470 Constanta, Romania 3. Department of Mathematics and Informatics, Faculty of Pharmacy, “Ovidius” University of Constanta, 900470 Constanta, Romania 4. Department of Botanics, Faculty of Pharmacy, “Ovidius” University of Constanta, 900470 Constanta, Romania 5. Department of Pharmaceutical Technology, Faculty of Pharmacy, “Ovidius” University of Constanta, 900470 Constanta, Romania 6. Department of Organic Chemistry, Faculty of Pharmacy, “Ovidius” University of Constanta, 900470 Constanta, Romania 7. Department of Microbiology and Immunology, Faculty of Dental Medicine, “Ovidius” University of Constanta, 900684 Constanta, Romania 8. Department of Dental Medicine, Faculty of Dental Medicine, “Ovidius” University of Constanta, 900684 Constanta, Romania
Abstract
The aim is to evaluate the antibacterial and antifungal properties of the extracts obtained from Lysimachia nummularia L. in order to be able to introduce these extracts into pharmaceutical products and obtain useful products in the infectious and antifungal pathology of the oro-dental cavity. Extracts from different parts of the studied species have been obtained and chemically characterized: the total polyphenols in 40% ethanolic extracts have been determined and the caffeic and chlorogenic acids and trans-resveratrol, bioactive compounds involved in the antimicrobial properties of the studied species, have been identified, separated, and quantitatively determined. The antibacterial and antifungal activities of the extract of Lisymachia nummularia L. were determined using the diffusion method against a set of bacteria isolated from samples from different patients with diseases of the oro-dental cavity. The extract of Lisymachia nummularia L. exhibited antimicrobial activity against Gram-positive bacteria more than Gram-negative, where the effect was weaker; however, it had no antifungal effects on Candida albicans. Another aspect that must be emphasized is that the best antibacterial results were obtained from the aerial segment of the plant, the part where the highest concentration of polyphenols was identified in the studies presented. These results indicate that the pharmacological effects of the studied bacterial species support the use of extracts in obtaining pharmaceutical products that can be used to optimize treatment schemes in oro-dental diseases.
Subject
Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science
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