Emerging Therapeutic Potential of Polyphenols from Geranium sanguineum L. in Viral Infections, Including SARS-CoV-2-Reference-Cited by-同舟云学术

Emerging Therapeutic Potential of Polyphenols from Geranium sanguineum L. in Viral Infections, Including SARS-CoV-2

Published:2024-01-19 Issue:1 Volume:14 Page:130
ISSN:2218-273X
Container-title:Biomolecules
language:en
Short-container-title:Biomolecules

Author:

Abarova Silviya¹^ORCID,Alexova Ralitza²,Dragomanova Stela³^ORCID,Solak Ayten⁴^ORCID,Fagone Paolo⁵^ORCID,Mangano Katia⁵^ORCID,Petralia Maria Cristina⁶^ORCID,Nicoletti Ferdinando⁵^ORCID,Kalfin Reni⁷⁸^ORCID,Tancheva Lyubka⁷

Affiliation:

1. Department of Medical Physics and Biophysics, Faculty of Medicine, Medical University of Sofia, Zdrave Str. 2, 1431 Sofia, Bulgaria

2. Department of Medical Chemistry and Biochemistry, Faculty of Medicine, Medical University of Sofia, Zdrave Str. 2, 1431 Sofia, Bulgaria

3. Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University of Varna, Tsar Osvoboditel Blvd 84A, 9002 Varna, Bulgaria

4. Institute of Cryobiology and Food Technologies, Cherni Vrah Blvd. 53, 1407 Sofia, Bulgaria

5. Department of Biomedical and Biotechnological Sciences, University of Catania, Via S. Sofia 89, 95123 Catania, Italy

6. Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy

7. Department of Biological Effects of Natural and Synthetic Substances, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str. 23, 1113 Sofia, Bulgaria

8. Department of Healthcare, South-West University “Neofit Rilski”, Ivan Mihailov Str. 66, 2700 Blagoevgrad, Bulgaria

Abstract

The existing literature supports the anti-inflammatory, antioxidant, and antiviral capacities of the polyphenol extracts derived from Geranium sanguineum L. These extracts exhibit potential in hindering viral replication by inhibiting enzymes like DNA polymerase and reverse transcriptase. The antiviral properties of G. sanguineum L. seem to complement its immunomodulatory effects, contributing to infection resolution. While preclinical studies on G. sanguineum L. suggest its potential effectiveness against COVID-19, there is still a lack of clinical evidence. Therefore, the polyphenols extracted from this herb warrant further investigation as a potential alternative for preventing and treating COVID-19 infections.

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

Link

https://www.mdpi.com/2218-273X/14/1/130/pdf

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