m6A Methylation in Regulation of Antiviral Innate Immunity-Reference-Cited by-同舟云学术

m6A Methylation in Regulation of Antiviral Innate Immunity

Published:2024-04-13 Issue:4 Volume:16 Page:601
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Karandashov Ivan¹^ORCID,Kachanov Artyom¹,Dukich Maria¹²,Ponomareva Natalia¹³⁴,Brezgin Sergey¹³^ORCID,Lukashev Alexander¹,Pokrovsky Vadim S.⁵⁶⁷^ORCID,Chulanov Vladimir⁸^ORCID,Kostyusheva Anastasiya¹,Kostyushev Dmitry¹³⁹^ORCID

Affiliation:

1. Laboratory of Genetic Technologies, Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia

2. Faculty of Virology, Lomonosov Moscow State University, 119234 Moscow, Russia

3. Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia

4. Department of Pharmaceutical and Toxicological Chemistry, Sechenov First Moscow State Medical University, 119048 Moscow, Russia

5. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia

6. Blokhin National Medical Research Center of Oncology, 117198 Moscow, Russia

7. Faculty of Biochemistry, RUDN University, 117198 Moscow, Russia

8. Department of Infectious Diseases, First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia

9. Faculty of Bioengineering and Biotechnologies, Lomonosov Moscow State University, 119234 Moscow, Russia

Abstract

The epitranscriptomic modification m6A is a prevalent RNA modification that plays a crucial role in the regulation of various aspects of RNA metabolism. It has been found to be involved in a wide range of physiological processes and disease states. Of particular interest is the role of m6A machinery and modifications in viral infections, serving as an evolutionary marker for distinguishing between self and non-self entities. In this review article, we present a comprehensive overview of the epitranscriptomic modification m6A and its implications for the interplay between viruses and their host, focusing on immune responses and viral replication. We outline future research directions that highlight the role of m6A in viral nucleic acid recognition, initiation of antiviral immune responses, and modulation of antiviral signaling pathways. Additionally, we discuss the potential of m6A as a prognostic biomarker and a target for therapeutic interventions in viral infections.

Funder

RSF

Ministry of Science and Higher Education of Russia

Academic leadership program Priority 2030

Publisher

MDPI AG

Link

https://www.mdpi.com/1999-4915/16/4/601/pdf

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