Individual Genomic Loci and mRNA Levels of Immune Biomarkers Associated with Pneumonia Susceptibility in Baladi Goats

Author:

Ateya Ahmed1,Al-Sharif Mona2,Abdo Mohamed34ORCID,Fericean Liana5,Essa Bothaina6

Affiliation:

1. Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt

2. Department of Biology, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia

3. Department of Animal Histology and Anatomy, School of Veterinary Medicine, Badr University in Cairo (BUC), Cairo 11829, Egypt

4. Department of Anatomy and Embryology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City 32897, Egypt

5. Department of Biology and Plant Protection, Faculty of Agricultural Sciences, University of Life Sciences King Michael I, 300645 Timisoara, Romania

6. Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt

Abstract

The effectiveness of breeding for inherent disease resistance in animals could be considerably increased by identifying the genes and mutations that cause diversity in disease resistance. One hundred and twenty adult female Baladi goats (sixty pneumonic and sixty apparently healthy) were used in this study. DNA and RNA were extracted from blood samples collected from the jugular vein of each goat. SLC11A1, CD-14, CCL2, TLR1, TLR7, TLR8, TLR9, β defensin, SP110, SPP1, BP1, A2M, ADORA3, CARD15, IRF3, and SCART1 SNPs that have been previously found to be associated with pneumonia resistance/susceptibility were identified via PCR-DNA sequencing. The pneumonic and healthy goats differed significantly, according to a Chi-square analysis of the discovered SNPs. The mRNA levels of the studied immune markers were noticeably greater in the pneumonic goats than in the healthy ones. The findings could support the significance of the use of immune gene expression profiles and nucleotide variations as biomarkers for the susceptibility/resistance to pneumonia and provide a practical management technique for Baladi goats. These results also suggest a potential strategy for lowering pneumonia in goats by employing genetic markers linked to an animal’s ability to fend off infection in selective breeding.

Funder

University of Life Sciences “King Mihai I” from Timisoara

Research Institute for Biosecurity and Bioengineering from Timisoara

Publisher

MDPI AG

Subject

General Veterinary

Reference85 articles.

1. Goat production in the world: Present situation and trends;Skapetas;Livest. Res. Rural. Dev.,2016

2. Gall, C. (1996). Goat Breeds Around the World, Margraf/FAO.

3. The initial domestication of goats (Capra hircus) in the Zagros Mountains 10,000 years ago;Zeder;Science,2000

4. Livestock genetic origins: Goats buck the trend;MacHugh;Proc. Natl. Acad. Sci. USA,2001

5. Review of modern strategies to enhance livestock genetic performance: From molecular markers to next-generation sequencing technologies in goats;Qureshi;J. Food Agric. Environ.,2014

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