Doxorubicin as a Potential Treatment Option in Canine Mammary Tumors
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Published:2023-11-14
Issue:11
Volume:10
Page:654
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ISSN:2306-7381
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Container-title:Veterinary Sciences
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language:en
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Short-container-title:Veterinary Sciences
Author:
Gherman Madalina Luciana12ORCID, Zanoaga Oana2, Budisan Liviuta2ORCID, Raduly Lajos2ORCID, Berindan-Neagoe Ioana2ORCID
Affiliation:
1. Experimental Center, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania 2. Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
Abstract
Canine mammary tumors represent one of the leading malignant pathologies in female dogs, displaying the importance of efficient therapeutic findings, besides the golden-standard surgery, able to limit the development of the disease. Studies in human cancers demonstrated that Doxorubicin presents a good effect in different biological processes like apoptosis, autophagy, the cell cycle, cell invasion, and the epithelial-to-mesenchymal transition. This study followed the effects of Doxorubicin on two canine mammary cancer cell lines P114 and CMT-U27. Doxorubicin treatment in both cell lines shows an inhibitory effect in cell proliferation and an alteration in expression of the EMT-related genes. The obtained results provide valuable information for revealing the link between Doxorubicin, phenotypic changes, and proliferation dynamics in canine mammary tumor models.
Funder
“Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania PDI-PFE-CDI2021
Subject
General Veterinary
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